| abstract |
FIELD: chemical-pharmaceutical industry, pharmacy. n SUBSTANCE: invention relates to a solid standard dosed formulation comprising atorvastatin or its pharmaceutically acceptable salt and a vehicle, or combination of vehicles that comprises above 50 wt.-% of diluting agents and less 5 wt.-% of alkaline substance as an additive. Indicated diluting agent represents lactose monohydrate, anhydrous lactose, microcrystalline cellulose or sodium chloride. The solid standard dosed formulation represents a table or capsule that is made without granulation step. Invention provides preventing segregation during making the standard dosed formulation and to provides the high dosing precision of atorvastatin. Excluding the granulation step results to enhancing effectiveness in producing the standard dosed medicinal formulation and without decreasing the rate of production of composition. n EFFECT: improved and valuable properties of compositions. n 5 cl, 1 dwg, 3 tbl, 7 ex |