| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c816365ca2cedee5cee1ff2558064e8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6811
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-643
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate |
2004-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2007-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72638ff598c32bc73037bb6896e3e5f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faa9be2371b320cbe51c74c0078e448f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f9f7f7dbd80c08de0d3f524a706d981
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50bb5373621a08bafebf704be467b273
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be7f2db7868564fdfeb461bbbe070e09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f879877541499f0b9351daf5cbb76350 |
| publicationDate |
2007-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2312868-C2 |
| titleOfInvention |
Physiologically active polypeptide conjugate showing prolonged half-time index in vivo |
| abstract |
FIELD: medicine, genetic engineering. n SUBSTANCE: invention relates to a method for preparing protein conjugates. Method involves adding immunoglobulin or physiologically active polypeptide to a single end of nonpeptide polymer having two reactive terminal groups in the presence of reducing agent. From a prepared reaction mixture the complex containing nonpeptide polymer bound with immunoglobulin or physiologically active polypeptide is isolated. Then free reactive terminal group of nonpeptide polymer of the complex is added covalently to immunoglobulin or physiologically active polypeptide in the presence of reducing agent to obtain a protein conjugate. Protein conjugate containing physiologically active polypeptide bound, nonpeptide polymer and immunoglobulin that are added one to another covalently in indicated order is isolated. Invention provides preparing a protein conjugate useful for manufacturing a polypeptide drug owing to its enhanced stability in vivo, prolonged blood half-time index and decreased immunogenic properties. n EFFECT: valuable medicinal properties of conjugate, improved preparing method. n 21 cl, 16 dwg, 14 tbl, 12 ex |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2656140-C2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11471513-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11123438-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2722374-C1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11472863-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2502803-C2 |
| priorityDate |
2003-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |