| abstract |
FIELD: medicine, oncology. n SUBSTANCE: in pre-surgical period in the 1 st , 3d, 5 th d of a 5-d-long irradiation course it is necessary to carry out a seance of distance gamma-therapy at single focal dosage (SFD) being 5 Gy at the background of a double intake of capecytabin at its daily dosage of 1.5 g/sq. m body surface. In the 2 nd and 4 th d at the background of a double intake of capecytabin at the same dosage, one should intrarectally introduce metronidasol at the rate of 10 g/sq. m body surface and after a 6-h-long exposure one should carry out a seance of distance gamma-therapy at SFD being 5 Gy. Moreover, metronidasol should be introduced as a composite mixture at the following ratios of the ingredients, weight%: metronidasol 12-22; sodium alginate 4-6; dimethyl sulfoxide 2; distilled water - up to 100. The innovation provides taking antilogarithms of the effect of radiomodifiers of different direction at the background of radiation therapy and, thus, the absence of locoregional relapses for the period of 2 yr, the decrease in the onset of distant metastases and the increased frequency in achieving radial pathomorphosis of degree III in the tumor. n EFFECT: higher efficiency of therapy. n 1 ex |