| abstract |
FIELD: organic chemistry, medicine, biochemistry, pharmacy. n SUBSTANCE: invention relates to using 4-fluoro-N-indane-2-ylbenzamide of the formula (I) as a pharmaceutical agent used in stimulation of endothelial nitrogen oxide (NO) synthase (eNOS) expression and in treatment and prophylaxis of some cardiovascular diseases (for example, stenocardia, acute coronary syndrome, cardiac insufficiency, myocardium infarction, insult, thrombosis, occlusive diseases of peripheral arteries, restenosis and so on), and to pharmaceutical compositions for the same designation. Early compound of the formula (I) is used in treatment of the central nervous system diseases owing its cholinergic activity. It was shown that compound of the formula (I) enhances eNOS transcription, reduces blood pressure value reliably in rats with hyperlipoproteinemia, decreases pathological formation of neointima by two-fold and shows anti-ischemic effect. n EFFECT: valuable medicinal properties of compound. n 10 cl, 1 ex |