| abstract |
FIELD: organic chemistry. n SUBSTANCE: invention relates to new amide-type carboxamide derivatives of formula [1] , wherein X represents -N= or -CH= group; R 1 represents halogen atom, lower alkyl and a like; R 1 represents -CO-R 21 -R 22 (meanings of R 21 and R 22 are as defined in claim 1); Y 1 and Y 2 are independently halogen atom, lower alkyl, lower alcoxy group, and a like; ring A represents phenyl and a like; or pharmaceutically acceptable salts thereof. Said derivatives are useful as FXa inhibitors. Also disclosed are pharmaceutical composition based on abovementioned compounds and uses thereof. n EFFECT: new amide-type carboxamide derivatives. n 7 cl, 105 ex |