| abstract |
FIELD: medicine. n SUBSTANCE: invention relates to application of pyrazoline derivatives of general formula I for prevention and/or treatment of precancerous or neoplastic processes, tumor angiogenesis, processes, associated with tumor necrosis factor (TNF) and other processes wherein inhibition of gene expression responsible to cyclooxygenase-2 (COX-2) synthesis in mammalian, including human has beneficial action. n EFFECT: new derivatives for prevention and/or treatment of diseases associated with cell proliferation. n 3 cl, 2 tbl, 10 ex |