http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2302417-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b98606d9cda02a2861481483e9fe4b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c90d4c9eb6f4837513dd1a4c6906f811 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2006-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c837a8d99243d8c06cad5673c18a4599 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3a5c695e75ca9798b951a67abc097f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7399850d24a538f75d6bb80bad34606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9d6475b65e0a12129b2f9e53a50c016 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e97c17b4158ac7f37f2f2513af72e6c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da5727719479563e00587dfe1f31c7b9 |
| publicationDate | 2007-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2302417-C1 |
| titleOfInvention | 1-oxo-3-(1h-indol-3-yl)-1,2,3,4-tetrahydroisoquinolines, methods of preparation thereof, combinatory library, and focused library |
| abstract | FIELD: organic synthesis. n SUBSTANCE: 1-oxo-3-(1H-indol-3-yl)-1,2,3,4-tetrahydroisoquinolines (including their cis- and trans-isomers) are depicted by following general formulae: (1) and (2), in which R 1 , R 2 , and R 4 independently represent cyclic system substituents selected from hydrogen atom and alkyl; R 3 is amino group selected from alkyl, cycloalkyl, and alkyl optionally substituted by aryl, heteroaryl, heterocyclyl, alkoxy, amino, alkylamino, and dialkylamino; R 5 and R 6 independently represent amino group substituents selected from hydrogen, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkyl, and alkyl optionally substituted by aryl, heteroaryl, heterocyclyl, cycloalkyl, cycloalkenyl, alkoxy, amino, alkylamino, dialkylamino, or arylalkylamino; or R 5 and R 6 , together with nitrogen atom to which they are linked, form optionally substituted aza-heterocycle. Method of preparing compounds 1 consists in reaction of corresponding indol-3-ylmethylamines with homophthalic anhydrides in an organic solvent. Compounds 2 are prepared by treating compounds 1 with thionyl chloride or 1,1'-carbonyldiimidazole to form corresponding derivatives, which are reacted with corresponding amines in an organic solvent. Compounds of invention exhibit proteinkinase inhibiting activities. Combinatory and focused libraries are also provided to reveal leading compounds. n EFFECT: expanded synthetic possibilities in quinoline series and increased choice of proteinkinase inhibitors. n 3 cl, 3 tbl, 3 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2472792-C2 |
| priorityDate | 2006-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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