| abstract |
FIELD: medicine, pharmacy. n SUBSTANCE: invention relates to a method for treatment of a patient with inflammatory disease or risk for its development. Method involves administration to a patient the following drugs: (i) tricyclic antidepressant, for example, amoxapine and (ii) corticosteroid, for example, prednisolon. Medicinal agents (i) and (ii) are administrated simultaneously or in interval in limits for 14 days in doses sufficient for inhibition of inflammation or reducing risk for its development. Also, invention relates to a pharmaceutical composition and pharmaceutical package containing medicinal agents (i) and (ii). Also, invention relates to a method for identification of combinations of compounds used in treatment of inflammation by assay of decreasing levels of pro-inflammatory cytokine in contact of immune cells with the combination of compound-candidate with (i) or (ii). Invention provides expanding assortment of anti-inflammatory agents and combinations, identification of such combinations and reducing toxicity in carrying out the anti-inflammatory treatment. n EFFECT: valuable medicinal properties of combinations, improved method of treatment. n 36 cl, 3 tbl, 3 ex |