| abstract |
FIELD: medicine, immunology, biotechnology. n SUBSTANCE: invention describes antibody raised against osteopontin that inhibits binding integrin and osteopontin or its fragment wherein integrin recognizes a sequence RGD or sequences SVVYGLR, SVAYGLR, SLAYGLR, SVAYGLK and SVAYRLK of osteopontin. Antibody is prepared in using peptide as an antigen comprising amino acid sequence RGDSVVYGLR or relates sequence RGDSVVYGLR. Also, invention proposes a medicinal agent for treatment of autoimmune disease and a method for treatment of autoimmune diseases based on indicated antibody wherein autoimmune disease is chosen from rheumatism, rheumatic arthritis and osteoarthritis. Invention describes using antibody for producing a medicinal preparation used in treatment of autoimmune disease chosen from rheumatism, rheumatic arthritis and osteoarthritis. Using the invention improved arthritic coefficient, delays development of arthritis and reduces legs edema in experimental arthritis in mice and can be used in medicine. n EFFECT: valuable medicinal properties of antibody. n 25 cl, 16 dwg, 13 tbl, 20 ex |