http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2299883-C2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d253e9e2d0f648792fac0070b34443f |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 |
filingDate | 2002-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2007-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06e44a491ac7b5f32371c8e926bdee53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f5c9743a24a5940b91770c9bbf65265 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b1ec0d4e1eab82574b02cdb45cc5923 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_435fe30713a0b46e3cc6d66d16f63f01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a84dc286c15610b82422d4bba76c0895 |
publicationDate | 2007-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | RU-2299883-C2 |
titleOfInvention | Spiropyrazole compounds, pharmaceutical composition containing thereof, method for modulation of opioid receptor and method for treatment using such compounds |
abstract | FIELD: chemical industry, organic chemistry, medicine, pharmacy. n SUBSTANCE: invention describes novel spiropyrazole compounds of the general formula (I): wherein W means hydrogen atom, (C 1 -C 10 )-alkyl, (C 3 -C 7 )-cycloalkyl, cyano-(C 1 -C 10 )-alkyl, -(C 1 -C 4 )-alkyl-COOV 1 wherein V 1 means hydrogen atom (H) or (C 1 -C 6 )-alkyl, -(C 1 -C 5 )-alkyl-C(=O)-W 1 wherein W 1 means amino-group, or -(C 1 -C 5 )-alkyl-NHS(=O) 2 -W 1 wherein W 1 means -(C 1 -C 10 )-alkyl; Q means phenyl; n mean a whole number 0 or 1; A, B and C mean hydrogen atom; Z means a simple bond, methylene or ethylene group; R 1 means (C 3 -C 12 )-cycloalkyl substituted optionally with (C 1 -C 10 )-alkyl, naphthyl, tetrahydronaphthyl, decahydronaphthyl, indenyl, norbornyl, dibenzocycloheptyl, 9-acenaphthyl, phenyl substituted optionally with benzyloxy-group, biphenyl or (C 1 -C 10 )-alkyl substituted optionally with 1-3 substitutes chosen from phenyl, cyano-group, -COOV 1 wherein V 1 means (C 1 -C 6 )-alkyl and -(C 1 -C 5 )-alkyl-C(=O)-W 1 wherein W 1 means amino-, (C 1 -C 4 )-alkylamino- or di-(C 1 -C 4 )-alkylamino-group; R 2 means (C 1 -C 10 )-alkyl, (C 3 -C 7 )-cycloalkyl or halogen atom. Also, invention to their pharmaceutically acceptable salts, solvates, pharmaceutical composition containing thereof, a method for treatment of pain and a method for modulation of pharmacological response of described ORL-1- or μ-receptors. Invention can be used in medicine. n EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. n 23 cl, 3 tbl, 5 ex |
priorityDate | 2001-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1417.