| abstract |
FIELD: organic chemistry, chemical technology, medicine, pharmacy. n SUBSTANCE: invention proposes compound of N-phenylarylsulfonylamide of the formula (I): wherein R 1 represents -COOH and so on; R 2 represents hydrogen atom, methyl and so on; R 3 and R 4 represent combination of methyl and methyl and so on; R 5 represents isopropyl and so on; Ar represents thiazolyl, pyridyl, 5-methyl-2-furyl wherein each is substituted optionally with methyl; n = 0 or 1, intermediate compound used in synthesis of this compound and a method for its synthesis. Compound of the formula (I) binds with prostaglandin E 2 receptors, in particular, with subtype of EP 1 and shows antagonistic properties. This compound shows low binding with protein and therefore it possesses the satisfactory activity in vivo. Also, invention claims a method for preparing a pharmaceutical composition possessing antagonistic activity with respect to EP 1 receptors that comprises compound of the formula (I) as active component and an inert excipient. Proposed pharmaceutical composition is designated for prophylaxis and/or treatment of pollakiuria (more frequent diuresis) or enuresis. n EFFECT: valuable medicinal properties of compound and pharmaceutical composition, improved method of synthesis. n 16 cl, 4 tbl, 3 sch, 270 ex |