| abstract |
FIELD: organic chemistry, medicine, pharmacy. n SUBSTANCE: invention relates to novel compounds of the formula (I): , wherein R 1 represents lower alkyl or lower alkyl substituted with phenyl; X represents a covalent bond; R 2 represents compound of the formula: R 4 -Z-Y-C≡C-, pyrazolyl substituted with phenyl, or pyrazolyl substituted with heteroaryl wherein Y represents alkylene; Z represents oxygen atom; R 4 represents phenyl substituted with halogen atom or (lower)-alkoxy-group comprising 1-3 carbon atoms; R 3 represents hydroxymethyl group. Also, invention relates to a method for synthesis of compounds of the formula (I) and to a pharmaceutical composition possessing effect of agonist of adenosine A3-receptors. Invention provides synthesis of novel biologically active compounds and pharmaceutical compositions based on thereof possessing effect of agonist of adenosine A3-receptors. n EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions. n 24 cl, 3 tbl, 18 ex |