| abstract |
FIELD: organic chemistry, pharmacy. n SUBSTANCE: invention relates to an improved chelate conjugates of the formula: wherein each R 1 , R 2 and R 3 represents independently R group; Y represents -(A) n -X-Z wherein X represents -NH-, -CO 2 -, -N(C=O)-; Z represents a biological group for directed delivery that is chosen from 3-20-membered peptide, substrate for enzyme, enzyme inhibitor or synthetic compound binding with receptor; -(A) n represent linker wherein each A represents independently -CR 2 -, -NRCO-, -CONR-, -CR 2 OCR 2 or polyalkylene glycol group; n represents a whole number from 2 to 10; each R group represents independently hydrogen atom (H) or (C 1 -C 10 )-alkyl, or two R groups in common with atoms to which they are added form (C 3 -C 6 )-carbocyclic saturated ring. Complexes with radioactive metals are useful as radioactive pharmaceutical preparation, especially, with 99m Tc. n EFFECT: valuable medicinal properties of conjugates. n 30 cl, 3 tbl, 4 dwg, 30 ex |