| abstract |
FIELD: organic chemistry, medicine, pharmacy. n SUBSTANCE: invention describes 8-amino-[1,2,4]triazolo-[1,5-a]pyridine-6-carboxylic acid amide of the formula (I): wherein R 1 means -NR'R'' wherein R'1 and R'' represent independently of one another lower alkyl, -(CH 2 ) n -C(O)NR a R b , -(CH 2 ) n -pyridinyl, -(CH 2 ) n -phenyl, -(CH 2 ) n -CN, -(CH 2 ) n -O-lower alkyl or -(CH 2 ) n -(C 3 -C 8 )-cycloalkyl; or R' and R'' form in common with nitrogen atom (N) 5- or 6-membered nonaromatic ring system wherein the latter can comprise additionally one heteroatom - oxygen (O) or sulfur (S) atom and wherein indicated ring system can be unsubstituted or substituted with one or two substitutes chosen from group consisting of lower alkyl, -C(O)NR a R b or group -(CH 2 ) n -O-lower alkyl; each R a and R b represents independently hydrogen atom or lower alkyl; R 2 means phenyl or heteroaryl representing pyridinyl, furanyl substituted possibly with halogen atom, or lower alkyl, thiophenyl substituted possibly with lower alkyl, or thiazolyl radical, and its pharmaceutically acceptable salts also. Compounds can be used in treatment of disease associated with adenosine A2-receptors. n EFFECT: valuable medicinal properties of compounds. n 12 cl, 1 tbl, 108 ex |