| abstract |
FIELD: organic chemistry, medicine, pharmacy. n SUBSTANCE: invention relates to novel compounds of the formula (I) and its pharmaceutically acceptable salts possessing properties of tumor necrosis factor (TNF-α) and to pharmaceutical composition based on thereof wherein R 1 means substituted or unsubstituted phenyl wherein substitutes are chosen from halogen atoms or halide-(C 1 -C 6 )-alkyl; R 4b is substituted or unsubstituted with 1-3 aryl substituted chosen from phenyl, naphthyl wherein substitutes are chosen from halogen atoms, (C 1 -C 6 )-alkyl, halide-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxyl, cyano-, amino-, (C 1 -C 6 )-acylamino-group, (C 1 -C 6 )-alkanesulfonyl, or two adjacent substitutes in benzene ring form dioxol group, or unsubstituted or substituted 6-membered nitrogen-containing heteroaryl with 1-3 nitrogen atoms in ring wherein substitutes are chosen from halogen atoms. n EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. n 15 cl, 9 sch, 10 tbl, 15 ex |