| abstract |
FIELD: organic chemistry, biochemistry, pharmacy. n SUBSTANCE: invention relates to derivatives of aromatic dicarboxylic acids of the general formula (I): n wherein means thiophene ring that can be unsubstituted or substituted with 1 or 2 substitutes; R1 and R2 are similar or different and mean hydrogen atom, branched or unbranched (C 1 -C 14 )-alkyl group that can be unsubstituted or substituted with one or some substitutes, carbocyclic group or heterocyclic group; R1 and R2 form in common with nitrogen atom 3-6-membered cycle, and to their enantiomers, diastereoisomers, racemates and their physiologically acceptable salts. Compounds possess inhibitory effect with respect to activity of histon deacetylase. Also, invention describes a medicinal agent based on compounds of the formula (I). n EFFECT: valuable medicinal and biochemical properties of derivatives. n 6 cl, 1 tbl, 18 ex |