http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2288212-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-329 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-324 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-2624 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-2615 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C47-198 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-324 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-329 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C47-12 |
| filingDate | 2003-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_967b9c6d8062774f250d96d6ff62c2ca |
| publicationDate | 2006-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2288212-C2 |
| titleOfInvention | Derivatives of polyetylene glycol aldehyde |
| abstract | FIELD: organic chemistry, chemical technology. n SUBSTANCE: invention relates to compounds of polyethylene glycol aldehyde (PEG-aldehydes), to method for synthesis of indicated compounds of polyethylene aldehyde, and to intermediate compounds that are used in synthesis of PEG-aldehydes. Method for synthesis of PEG-aldehydes involves pyrolysis of indicated intermediate substances. Indicated aldehydes of polyethylene glycols represent specific reagents for formation of PEG-peptides and other biomolecules by N-terminal amino acid residues, i. e. PEG-aldehydes form conjugate with N-terminal α-amino-group of biomolecule or protein with formation of a stable bond as secondary amine between PEG and biomolecule or protein. Also, in PEG-polypeptides the specific N-terminal bond is formed that excludes formation of cross-linking bonds or formation of some derivatives of the same polypeptide. Depending on chosen aldehyde PEG can bind covalently with biomolecule by one terminal group (monofunctional PEG-aldehyde) or by two terminal groups (bifunctional PEG-aldehyde). The advantage of PEG conjugates with biomolecules involves their enhanced retaining and delayed metabolism in body. n EFFECT: improved preparing method, improved and valuable properties of compounds. n 17 cl, 7 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2463317-C2 |
| priorityDate | 2002-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 168.