http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2287524-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b297d98a67e5769763260d5c27f6571 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-417 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate | 2005-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e39238273446af9eb29522600c80039 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d1fe873735530e5cefef9d40f70203f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c15383f9b531886e8f666c649de4364 |
| publicationDate | 2006-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2287524-C1 |
| titleOfInvention | Aspartyl derivatives of histamine, method for their preparing, pharmaceutical composition and their using as modulators of enzyme activity of antioxidant protection |
| abstract | FIELD: bioorganic chemistry, biochemistry, pharmacy. n SUBSTANCE: invention relates to novel aspartyl derivatives of histamine of the general formula (I): , wherein R means hydrogen atom (H), or , or that are able to modulate activity of enzymes of antioxidant protection - superoxide dismutase (SOD) and catalase. Also, invention relates to using the known compounds of the general formula (I) for the same designation wherein at the same values of X the value R represents acetyl group, and to their pharmaceutically acceptable salts. Also, invention relates to a pharmaceutical composition possessing capacity to modulate activity of SOD and catalase and comprising the effective amount of compound of the general formula (I), and to a method for synthesis of compounds of the general formula (I). Method involves interaction of pentafluorophenyl ester N α -Z-, β- or α-benzyl ester of aspartic acid with histamine followed by hydrogenolysis without isolation of intermediated protected derivatives of aspartyl histamine. n EFFECT: improved method of synthesis, valuable biochemical properties of derivatives. n 12 cl, 3 tbl, 2 sch, 2 dwg, 8 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020091632-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2709529-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2725770-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2725881-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2679636-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2719464-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2721421-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2665688-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2685277-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019226082-A1 |
| priorityDate | 2005-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 333.