| abstract |
FIELD: organic chemistry, chemical technology, biochemistry, pharmacy. n SUBSTANCE: invention relates to novel derivatives of heteroaryl-substituted aminocyclohexane of the formula (I) and their pharmaceutically acceptable salts possessing the inhibitory effect on activity of 2,3-oxydosqualene-lanosterolcyclase (OSC). In the formula (I) V means a simple bond, oxygen atom (O), -CH=CH-CH 2 - or -C≡C-; m and n = 0-7 independently of one another and m+n = 0-7 under condition that m is not 0 if V means O; o = 0-2; A 1 means hydrogen atom, lower alkyl, hydroxy-lower alkyl or lower alkenyl; A 2 means lower alkyl, or A 1 and A 2 are bound and form 5-6-membered cycle, and -A 1 -A 2 - means (C 4 -C 5 )-alkylene; A 3 and A 4 mean hydrogen atom independently of one another; A 5 means hydrogen atom, lower alkyl; A 6 means pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl optionally substituted with one substitute chosen independently from the group including halogen atom, lower alkyl, lower alkoxy-group and 5-6-membered heteroaryl comprising nitrogen or sulfur atom as a heteroatom, Also, invention relates to a pharmaceutical composition and using proposed compound for preparing medicinal agents. Proposed compounds can be used in treatment of such diseases as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycosis, parasitic infections, cholelithiasis, tumors and/or hyperproliferative disorders, and/or in disordered tolerance to glucose and diabetes mellitus. n EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. n 24 cl, 7 sch, 28 ex |