| abstract |
FIELD: organic chemistry, biochemistry, virology. n SUBSTANCE: invention relates to inhibition of human immunodeficiency virus (HIV) that is identified as etiological agent responsible for the acquired immunodeficiency syndrome (AIDS) that represents the lethal disease characterizing by damage of immune system, inability for the life safe and to resist against infections. Invention proposes inhibitors of integrase represented by the formula (I): n wherein corresponding values of radicals are given in the invention description. The aim of the present invention involves providing preparing a pharmaceutical composition useful for inhibition of activity of HIV integrase that involves the therapeutically effective dose of compound of the formula (I) and their pharmaceutically acceptable salts, solvates and a pharmaceutically acceptable carrier. n EFFECT: valuable medicinal properties of inhibitors. n 16 cl, 6 sch, 42 ex |