http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2280649-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b297d98a67e5769763260d5c27f6571 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2004-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9670cecd2f11ae8f2ed2107b26805ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e39238273446af9eb29522600c80039 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d1fe873735530e5cefef9d40f70203f |
| publicationDate | 2006-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2280649-C1 |
| titleOfInvention | Hemin-peptides, their pharmaceutically acceptable salts, pharmaceutical composition and using as anti-tumor agents |
| abstract | FIELD: chemistry of natural organic compounds, medicine, oncology, pharmacy. n SUBSTANCE: invention proposes hemin-peptides of the general formula (I): wherein R 1 and R 2 are substitutes that can represent peptide consisting of 1-7 amino acids wherein carboxyl groups of peptide can be modified with (C 1 -C 8 )-alkyl ester and by-side groups of amino acids of peptide can be protected and chosen from the group wherein: at R 1 means: Arg-Trp-His-Arg-Leu-Lys-Glu(OMe)-OH; R 2 means -OH at R 1 - Trp-His-Arg-Leu-Lys-Glu(OMe)-OH; R 2 means -OH; at R 1 - SerOMe; R 2 - SerOMe, at R 1 - AspOH; R 2 - AspOH; Me represents Fe; Y represents Cl wherein carboxyl group of hemin can be modified with methyl or (C 2 -C 8 )-ester or physiologically acceptable salt; or its pharmaceutically acceptable salts. hemin-peptides possess capacity to induce apoptosis of cells and show anti-tumor effect and can be used for biomedicinal aims. n EFFECT: valuable medicinal properties of hemin-peptides. n 5 cl, 1 tbl, 9 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-020802-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015031854-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011031187-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8906897-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9605013-B2 |
| priorityDate | 2004-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.