| abstract |
FIELD: organic chemistry, medicine, pharmacy. n SUBSTANCE: invention relates to substituted glutarimides of the general formula (I): wherein X means group of the formula -(CH 2 ) n -(CR 8 R 9 ) p -Z-(CR 8 R) m wherein Z means sulfur (S) or oxygen (O) atom, SO- or SO 2 -group, residue -NR 8 (optionally as N-oxide) or the group -CR 8 R 9 ; m and p mean 0 or 1; n means 0, 1, 2 or 3, and m, n and p can't mean 0 simultaneously; R 1 and R 2 mean carboxyl, ester or acyl group and others; R 3 means hydrogen atom, hydroxyl group and others; R 4 means hydrogen atom, (C 1 -C 3 )-alkyl group, fluorine atom, trifluoromethyl group; R 8 and R 9 means hydrogen atom, benzyl, alkyl and others, and to their physiologically acceptable salts also. Compounds of the formula (I) possess immunomodulating effect and can be used in treatment of angiopathy and/or oncohematological diseases. n EFFECT: improved preparing method, valuable medicinal properties of compounds. n 15 cl, 1 tbl, 20 ex |