| abstract |
FIELD: medicine, pharmacy. n SUBSTANCE: invention relates to the injectable galenic composition used in diagnosis or photodynamic therapy and to a method for its preparing. The composition comprises the following components: compound of the general formula (I) given in the invention description wherein R 2 means hydrogen atom, hydroxyl group (-OH) or group -COOR 4 wherein R 4 means hydrogen atom or (C 1 -C 12 )-alkyl, or (C 3 -C 12 )-cycloalkyl; R 3 means hydrogen atom, -OH or (C 1 -C 12 )-alkyl, or (C 1 -C 12 )-alkoxyl, and symbol * means asymmetric carbon atom in form of alkaline metal salt in the amount not exceeding 1 weight% to the total weight of the composition (10 mg/ml) as a photosensitizing agent and a filling agent in an aqueous phase comprising at least a mixture of benzyl alcohol and ethanol or propylene glycol as a solubilizing agent for a photosensitizing agent and a surface-active substance in the amount not exceeding 20 wt.-% to the total mass of the composition under condition that when Cremophore represents a surface-active substance then its amount must not exceed 5 weigh% to the total weight of the composition. n EFFECT: improved preparing method, valuable properties of composition. n 18 cl, 7 tbl |