http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2270196-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2001-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa633a836193d4194a46eef2655f2201 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06802f48ff0ecc016d9dd6e7a2b15d16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b75c86d3718af183be53ad3d5028cff9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fb3ce3f961a8eddb57fa3003c650365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3953376618af1eef7838aae1dba2ecf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56244caa95dc4811d0278217e291de42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41895f7a3daba38540f1e489b928488e |
| publicationDate | 2006-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2270196-C2 |
| titleOfInvention | Indole derivatives, method for their preparing, medicinal agent and method for inhibition of tumor cells proliferation |
| abstract | FIELD: organic chemistry, medicine, oncology, pharmacy. n SUBSTANCE: invention relates to new derivatives of indole of the formula (1): wherein R means hydrogen atom (H), linear or branched (C 1 -C 6 )-alkylcarbonyl but preferably acetyl, linear or branched (C 1 -C 6 )-alkoxycarbonyl, (C 2 -C 6 )-alkynyl but preferably ethynyl or propargyl; R 1 means unsaturated or aromatic (C 3 -C 10 )-heterocycle comprising at least one heteroatom taken among nitrogen (N) and sulfur (S) atoms and possibly substituted with at least one linear or branched (C 1 -C 6 )-alkyl or (C 1 -C 2 )-alkoxy-group and wherein said heterocycle is joined to nitrogen amide atom directly with exception for of substituted or unsubstituted 2-, 4-pyrimidyl, substituted or unsubstituted 2-, 3-, 4-pyridyl, substituted or unsubstituted indolyl, substituted or unsubstituted dithiacyclopentyl, substituted or unsubstituted 2-, 3-, 4- or 8-quinolyl residues; R 2 means hydrogen atom (H) substituted with at least one phenyl, (C 1 -C 6 )-alkyl wherein phenyl residue can be free or comprises from 1 to 5 similar or different halogen atoms but preferably chlorine, bromine or iodine atoms; R 3 and R mean hydrogen atom; Z 1 and Z 2 mean independently oxygen or sulfur atoms. Also, invention relates to physiologically acceptable salts of the proposed compounds. Compounds of the formula (1) inhibit the tumor cells proliferation that allows their using as an antitumor medicinal agent. Also, invention describes a method for preparing compound of the formula (1). n EFFECT: improved preparing method, valuable medicinal properties of compounds and agent. n 9 cl, 3 sch, 2 tbl, 18 ex |
| priorityDate | 2000-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 123.