| abstract |
FIELD: organic chemistry, medicine, cardiology, biochemistry. n SUBSTANCE: invention relates to benzoyl guanidines of the formula (I): wherein R1 means -CF 3 ; R2 means -Y-para-(C 6 H 4 )-R11, -Y-meta-(C 6 H 4 )-R11 or -Y-ortho-(C 6 H 4 )-R11 wherein R11 means (C 1 -C 9 )-heteroaryl comprising two or more nitrogen atoms adjoining across nitrogen (N) atom; Y means oxygen atom; R3 means hydrogen atom; R4 means (C 1 -C 4 )-alkyl, and to their pharmaceutically acceptable salts. Indicated compounds elicit very high activity with respect to inhibition of Na + /H + exchange and improved water solubility and therefore they can be used as anti-arrhythmic medicinal agents with cardioprotective component for prophylaxis of infarction and treatment of infarction and for treatment of stenocardia. Also, proposed compounds inhibit pathophysiological processes in arising disorders induced by ischemia, in particular, in treatment of cardiac arrhythmia induced by ischemia. n EFFECT: improved preparing method, improved treatment and prophylaxis, valuable medicinal properties of compounds. n 17 cl, 2 ex |