http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2267485-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4741 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2003-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b676d9ccd3f25516c7fdc6f8d62000f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8954b589d06776241e422745dd24111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee32de8d67e437c71cbd24fa83faca20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f5f61016052dd252965f6a3619030c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb26364904ab81cd7d382612fcfdf084 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48809910698c250a4a2793f85e91198f |
| publicationDate | 2006-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2267485-C2 |
| titleOfInvention | Derivatives of 3-aminomethylquinolone-2 as inhibitors of no-synthetase and method for their preparing, biologically active compounds and pharmaceutical composition based on thereof |
| abstract | FIELD: organic chemistry, biochemistry, medicine, pharmacy. n SUBSTANCE: invention relates to new derivatives of 3-aminomethylquinolone-2 of the general formula (1) n (2) n or (3) wherein R 1 means hydrogen atom (H) or Alk; R 2 is taken among Alk; -OAlk, -SCH 3 , -Hal, -CF 3 , 3,4-OCH 2 CH 2 O-, 3,4-OCH 2 O-, 4-OCF 3 , 2-Ph, -OPh, -NHCOR, 2-OCH 3 , 5-Ph, 4-Obzk, 3-NO 2 , 2-CH 3 , 5-iPr, di-OAlk, di-Hal; or R 2 represents halogen atom and alkyl group, or halogen atom and alkoxy-group taken simultaneously and independently of one another; or R 2 represents the group -CONR 4 R 5 wherein each R 4 and R 5 means independently of one another the group Alk, or they form the group -(CH 2 ) n - wherein n = 2-6. R means -CH 3 ; R 3 means hydrogen atom (H); X is taken among hydrogen atom (H), 6-(C 1 -C 3 )-Alk, 6-iPr, 6-iBu; 7-(C 1 -C 2 )-Alk, 8-(C 1 -C 2 )-Alk, 6-(C 1 -C 2 )-OAlk, 6-OCF 3, 7-(C 1 -C 2 )-Alk, 7-SCH 3 , 6,7-OCH 2 O-, 6,7-OCH 2 CH 2 O-, 5,6,7-OCH 3 , 6-F; X and Y are similar or different and taken among 7,8-CH 3 , 6,8-CH 3 , 5,8-CH 3 , 5,7-CH 3 , 6,7-CH 3 , 6,7-OCH 3 , 6-CH 3 , 7-Cl. Also, invention relates to a method for preparing indicated compounds and to pharmaceutical composition inhibiting activity of NO-synthetase based on these compounds. Invention provides preparing new compounds and pharmaceutical composition based on thereof for aims preparing medicinal agents for treatment diseases associated with hyperactivity of phagocytizing cells, for example, rheumatic arthritis, asthma and others. n EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds and pharmaceutical composition. n 19 cl, 1 tbl, 95 ex |
| priorityDate | 2003-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 203.