| abstract |
FIELD: organic chemistry, biochemistry, pharmacy. n SUBSTANCE: invention relates to new anellated carbamoyl azaheterocycles of the general formula (1) n or (2) possessing the inhibitory effect on protein kinase activity, a focused library comprising these compounds, and pharmaceutical composition based on thereof. In the general formula (1) or (2) R 1 represents hydrogen atom or optionally substituted (C 1 -C 6 )-alkyl; R 2 and R 3 represent independently of one another hydrogen atom, inert substitute, optionally substituted (C 1 -C 6 )-alkyl, optionally substituted (C 3 -C 8 )-cycloalkyl, optionally substituted phenyl, optionally substituted aryl, optionally substituted heterocyclyl; R 4 represents optionally substituted (C 1 -C 6 )-alkyl, optionally substituted (C 3 -C 8 )-cycloalkyl, optionally substituted phenyl, optionally substituted aryl, optionally substituted heterocyclyl; A and B in common with carbon and nitrogen atoms joined to the form an optionally substituted and optionally condensed azaheterocycle; D and F in common with carbon atoms joined form an optionally substituted and optionally condensed phenyl or aryl, optionally substituted and optionally condensed azaheterocycle. K and L in common with carbon and nitrogen atoms joined to them form an optionally substituted azaheterocycle. Also, invention related to methods for preparing compounds of the general formulae (1) or (2). n EFFECT: improved preparing methods. n 10 cl, 2 sch, 25 tbl, 7 ex |