http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2266905-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 |
| filingDate | 2000-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80b3c0cbc63cad081727dee4ca28b6ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c83d2985c79df5050879a48312829e41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53f00108fd37a9aeb3699b4cecb972db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a983d1cbdcf3721ed9b7bfd3482f592 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff3bf0eec925bf02de8938702f2f0ec7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_291a02405d7b07c5cf7490b2aef8b147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31ed3a491927f6a70c6b64a4483fe138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc6fc603d361df4fcf074183e5d885bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ea516d1c9026b925cba0f63a9c16122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25b642b937b848997d2d2256462a0b3a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d81f5f7b8e9503e677b7d87d137b0ad |
| publicationDate | 2005-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2266905-C2 |
| titleOfInvention | Quinuclidine compounds, medicinal agents comprising thereof and methods for preparing quinuclidine compounds |
| abstract | FIELD: organic chemistry, chemical technology, medicine, biochemistry. n SUBSTANCE: invention relates to quinuclidine compounds of the formula (I) , its salts or their hydrates wherein R 1 represents hydroxyl group; W represents: (1) -CH 2 -CH 2 -; 2) -CH=CH-, or 3) -C≡C-; HAr represents 5-10-membered aromatic heterocycle comprising 1-2 heteroatoms taken among nitrogen atom and sulfur atom that in addition to the group -X-Ar can be substituted with 1-3 groups taken among: (1) halogen atom; (2) (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl or (C 2 -C 6 )-alkynyl group substituted optionally with: (a) hydroxy-group; (b) (C 1 -C 6 )-alkoxycarbonyl; (c) (C 1 -C 6 )-alkanoyl optionally substituted with (C 1 -C 6 )-alkoxy-group; (d) hydroxylated (C 3 -C 8 )-cycloalkyl; (e) (C 1 -C 6 )-alkoxy-group; (f) 5-6-membered aromatic heterocycle comprising 1-3 heteroatoms taken among nitrogen atom, sulfur atom and oxygen atom, or (g) cyano-group; (3) (C 1 -C 6 )-alkoxy-group optionally substituted with: (a) hydroxy-group; (b) (C 1 -C 6 )-alkoxy-group optionally substituted with (C 1 -C 6 )-alkoxy-group; (c) halogen atom; (d) 4-6-membered nonaromatic heterocycle comprising 1-3 heteroatoms taken among nitrogen atom, sulfur atom and oxygen atom; (e) 5-6-membered aromatic heterocycle comprising 1-3 heteroatoms taken among nitrogen atom, sulfur atom and oxygen atom; (4) (C 1 -C 6 )-alkylthio-group optionally substituted with (C 1 -C 6 )-alkoxy-group or hydroxy-group; (5) 5-6-membered heterocyclyloxy-group comprising 1-2 oxygen atoms in heterocycle; (6) amino-group represented by the formula: -N(R 3 )R 4 wherein R 3 and R 4 are similar or different and each represents hydrogen atom or group taken among: (a) (C 1 -C 6 )-alkyl group; (b) (C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl group; (c) carbonyl substituted with (C 6 -C 14 )-aryl; (d) (C 6 -C 14 )-arylsulfonyl or (e) 4-6-membered nonaromatic heterocycle comprising 1-3 heteroatoms taken among nitrogen atom, sulfur atom and oxygen atom; (7) (C 3 -C 8 )-cycloalkyl or cycloalkenyl hydrocarbon group optionally substituted with: (a) oxo-group or (b) hydroxy-group; (8) (C 6 -C 14 )-aromatic hydrocarbon ring optionally substituted with: (a) (C 1 -C 4 )-alkylene dioxy-group or (b) hydroxy-group; (9) 5-6-membered aromatic heterocycle comprising 1-3 heteroatoms taken among nitrogen atom, sulfur atom and oxygen atom optionally substituted with: (a) cyano-group or (b) (C 1 -C 6 )-alkoxy-group; (10) 4-6-membered nonaromatic heterocycle comprising 1-3 heteroatoms taken among nitrogen atom, sulfur atom and oxygen atom optionally substituted with one or some groups taken among: (a) hydroxy-group; (b) halogen atom; (c) cyano-group; (d) (C 1 -C 6 )-alkoxycarbonyl; (e) (C 1 -C 6 )-alkyl; (f) (C 1 -C 6 )-alkoxy-group that is optionally substituted with halogen atom or (C 1 -C 6 )-alkoxy-group; (g) (C 1 -C 6 )-alkanoyl; (h) (C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl; (i) oxo-group; (j) (C 1 -C 4 )-alkylenedioxy-group; (k) (C 3 -C 8 )-cycloalkylalkoxy-group or (C 3 -C 8 )-cycloalkenylalkoxy-group; (11) carbamoyl of the formula: -CO-N(R 5 )R 6 wherein R 5 and R 6 can be similar or different and represent hydrogen atom, (C 6 -C 14 )-aryl wherein indicated aryl is optionally substituted with halogen atom, or (C 3 -C 8 )-cycloalkyl; or R 5 and R 6 form in common 3-6-membered ring; (12) carbonyl optionally substituted with (C 1 -C 6 )-alkoxy-group; X represents: (1) a simple bond; (2) (C 1 -C 6 )-alkylene chain; (3) (C 1 -C 6 )-alkenylene chain; (4) (C 1 -C 6 )-alkynylene chain; or (5) formula: -Q- wherein Q represents oxygen atom or sulfur atom; Ar represents: (1) (C 6 -C 14 )-aromatic hydrocarbon ring optionally substituted with one or some groups taken among: (a) halogen atom; (b) (C 1 -C 4 )-alkoxy-group or (c) (C 1 -C 6 )-alkylthio-group; or (2) 5-6-membered aromatic heterocycle comprising 1-2 heteroatoms taken among nitrogen atom and sulfur atom. Compounds of the formula (I) show inhibitory activity with respect to a squalene-synthesizing enzyme. Also, the invention relates to an inhibitor of squalene-synthesizing enzyme and the corresponding medicinal composition based on compound of the invention, a method for prophylaxis and treatment of disease wherein inhibition of squalene-synthesizing enzyme is effective. Also, invention proposes some methods for preparing compounds of the formula (I). n EFFECT: improved preparing method, valuable of medicinal and biochemical properties of com[pounds and composition. n 25 cl, 10 tbl, 214 ex |
| priorityDate | 1999-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1324.