http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2265608-C1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F1-00 |
| filingDate | 2004-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9e7a6150cf35358a0dbc4ac6641ed06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e126fce640693bd75634f918bcfc5e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff373f3dd65c9ca36f4212c6d559754e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_654eb9f255da47b4deb33dd23e24ad3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a66064a06b577d4e14dbbc4edb2bd981 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef7e04bbbc869b9840d71e9675be1088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f208009998f8c5145ebe6b07d32d3518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c17db4cba1c6a51f9d2432da56b5664 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_559734d31726ff4241a327d0e26c36d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee1de70d73a91eb070a7cc838b55b08b |
| publicationDate | 2005-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2265608-C1 |
| titleOfInvention | Derivatives of aminothiols |
| abstract | FIELD: organic chemistry, medicine, physiology. n SUBSTANCE: invention relates to agents for regulation (maintaining or suppression) of physical working ability and/or adaptation to different variants represented by solvated complex compounds of the general formula (I): Kat m+ [L 1 q EL 2 ]An n- x p.Solv (I) wherein L 1 means aminothiols of the formula: R 1 NHCH(R 2 )(CH 2 ) 1-2 SR 3 wherein R 1 means hydrogen atom (H), (C 1 -C 20 )-alkyl or RCO; R means (C 1 -C 19 )-alkyl; R 2 means H or carboxyl; R 3 means H, (C 1 -C 20 )-alkyl, (C 2 -C 20 )-alkenyl or benzyl; q = 1, 2 or 3; L 2 means halogen atom, water and/or organic ligand. For example, bis-(N-acetyl-L-cysteinato)aquozinc (II) diheptahydrate suppresses physical working ability and in the dose 50 mg/kg increases reviving time of mice by 6 times and cats - by 2.8fold under conditions of acute hypoxia with hypercapnia, and increases reviving time of mice by 4 times under conditions of acute hypobaric hypoxia. Under the same conditions the known antihypoxic agents amtizol, acizol or mexidol are inactive or less active significantly by their activity. Bis-(N-acetyl-L-cysteinato)-ferrous (II) pentahydrate is more active as compared with the known antihypoxic agents and protects experimental animals in 4 variants of hypoxia. Bis-(N-acetyl-L-cysteinato)zinc (II) sulfate octahydrate is similar to enumerated compounds by its antihypoxic activity. n EFFECT: valuable medicinal properties of compounds. n 4 cl, 1 dwg, 11 tbl, 33 ex |
| priorityDate | 2004-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 204.