| abstract |
FIELD: organic chemistry, medicine, pharmacy. n SUBSTANCE: invention relates to derivatives of imidazole of the formula (I): n or its pharmaceutically acceptable salts wherein X represents -CH 2 -(CH 2 ) p -, -O-; R 1 represents phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (C 3 -C 7 )-cycloalkyl wherein indicated phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (C 3 -C 7 )-cycloalkyl are substituted optionally with 1-3 substitutes taken independently among halogen atom, -OH, halogen-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxy group and OH-(C 1 -C 6 )-alkyl; R 2 represents hydrogen atom (H) or (C 1 -C 6 )-alkyl; R 3 represents H or (C 1 -C 6 )-alkyl; R 4 represents H or (C 1 -C 6 )-alkyl; R 5 represents H, or R 5 and R 7 form in common a bond; each R 6 represents independently halogen atom, -OH, halogen-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxy group or OH-(C 1 -C 6 )-alkyl; R 7 represents H, or R 7 and R 5 form in common a bond; each R 8 represents independently -OH, (C 1 -C 6 )-alkyl, halogen-(C 1 -C 6 )-alkyl or (C 1 -C 6 )-alkoxy group; m = 0, 1, 2 or 3; n = 0 or 1; p = 0 or 1; r = 0 or 1; t = 0. Also, invention relates to a method for preparing compounds of the formula (I) and to a pharmaceutical composition showing affinity to alpha-2-adrenoceptors based on these compounds. Invention provides preparing new compounds and pharmaceutical composition based on thereof used in aims for treatment of neurological disturbances, psychiatric disorders or disturbances in cognitive ability, diabetes mellitus, lipolytic diseases, orthostatic hypotension or sexual dysfunction. n EFFECT: improved preparing method, valuable medicinal properties of compounds and compositions. n 25 cl, 1 tbl, 14 ex |