http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2265055-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
| filingDate | 2004-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe308740b078ea793f2226ca4218056b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_234d2f746797d61018d7503db2d411f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b714f10504f35495570d85d6c08f91a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3125a9b5625bb2a0d1fe60461d6b807 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0381c0a8fc1134cac46ec31ae99aa77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc3a1fb96897b9adc051165e2f2247d1 |
| publicationDate | 2005-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2265055-C2 |
| titleOfInvention | Recombinant plasmid expressing module polypeptide for delivery of photosensitizer and strain escherichia coli vkpm b-8356 - producer of module polypeptide |
| abstract | FIELD: biotechnology, microbiology, genetic engineering. n SUBSTANCE: invention proposes a new recombinant plasmid pR752 (5269 pair bases) comprising genetic construction under control of bacteriophage T5 promoter and encoding a module polypeptide consisting of 6 histidine residues, hemoglobin-like protein of E. coli, modified fragment of large T-antigen SV-40, translocation domain of diphtheria toxin, spacer sequence (Gly-Ser) 5 and human epidermal growth factor (6 His-HMP-NLS-Dtox-(Gly-Ser) 5 -EGF) and designated for the directed transfer of photosensitizers into target-cell nuclei. By transformation of the strain E. coli M15 (rep 4) with plasmid pR752 the recombinant strain E. coli VKPM B-8356 as a producer of new polypeptide vector is prepared. The usage of this new strain is able to enhance the effectiveness of effect of photosensitizers by some orders. Invention can be used in medicinal-biological industry in preparing agents providing the directed transport of photosensitizing agents into tumor cell nuclei. n EFFECT: valuable biological and medicinal properties of polypeptide. n 3 dwg, 4 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2639501-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2706698-C1 |
| priorityDate | 2004-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.