| abstract |
FIELD: organic chemistry, medicine, pharmacology, pharmacy. n SUBSTANCE: invention relates to derivatives of 1,2-dihydropyridine of the general formula (I) n , n their salts or hydrates wherein Q means oxygen atom (O); R 1 , R 2 , R 3 , R 4 and R 5 are similar or different of one another and each radical means hydrogen atom, halogen atom, (C 1 -C 6 )-alkyl group or group represented by the formula: -X-A (wherein X means a simple bond, (C 1 -C 6 )-alkylene group); A means (C 6 -C 14 )-aromatic hydrocarbocyclic group or 5-14-membered aromatic heterocyclic group. Also, invention describes a method for preparing compounds and pharmaceutical composition. Compounds possess the strong inhibitory effect on AMPA receptors and/or kainate receptors. n EFFECT: improved preparing method, valuable properties of compounds and composition. n 99 cl, 1 tbl, 414 ex |