| abstract |
FIELD: organic chemistry, medicine, neurology, pharmacy. n SUBSTANCE: invention relates to 3-substituted 4-(phenyl-N-alkyl)piperidines of the general formula (1): n n n n wherein R 1 represents -OSO 2 CF 3 , -OSO 2 CH 3 , -SOR 3 , -SO 2 R 3, - COR 3 ; R 2 represents (C 1 -C 4 )-alkyl, allyl, -CH 2 CH 2 OCH 3 , -CH 2 CH 2 CH 2 F, -CH 2 CF 3 , 3,3,3-trifluoropropyl, 4,4,4,-trifluorobutyl group; R 3 represents (C 1 -C 3 )-alkyl, -CF 3 , and their pharmaceutically acceptable salts also. Also, invention discloses pharmaceutical compositions of abovementioned compounds and methods wherein abovementioned compounds are used in treatment of the central nervous system disturbances. n EFFECT: improved methods for treatment, valuable medicinal properties of compounds and compositions. n 31 cl, 47 ex |