| abstract |
FIELD: organic chemistry, medicine, pharmacy. n SUBSTANCE: invention relates to novel biologically active compounds. Invention describes compounds or their salts of the general formula (I): A-B-N(O) s (I) wherein s = 2; A means R-T 1 - wherein R represents radical of a medicinal substance under condition that a medicinal substance by the formula R-T 1 -Z or R-T 1 -OZ wherein Z represents hydrogen atom (H) or (C 1 -C 5 )-alkyl is taken among paracetamol, salbutamol, ambroxol, alendronic acid,, cetirizine, ampicillin, aciclovir, doxorubicin, simvastatin, diphylline, tacrine, clopidogrel, dimethylomeprazol, diclofenac, ferulic acid, enalapril, propranolol, benfurodil hemisuccinate, tolrestate or sulindac; T 1 means (CO), oxygen atom (O) or NH; B means T B -X 2 -O- wherein T B means bivalent radical R 1B -X-R 2B wherein R 1B and R 2B are similar or different and represent linear or branched (C 1 -C 6 )-alkylenes and X represents a bond, oxygen (O), sulfur (S) atom or NR 1C wherein NR 1C represents hydrogen atom (H) or linear or branched (C 1 -C 6 )-alkyl; corresponding precursor B is represented by the formula -T B -X 2 -OH wherein T B means (CO) and free valence in T B represents -OZ wherein Z is determined above, or T B means oxygen atom (O), and free valence in T B represents hydrogen atom (H) under condition that in the formula (I) when X 2 in precursor B represents linear or branched (C 2 -C 20 )-alkylene then a medicinal substance by the formula R-T 1 -Z or R-T 1 -OZ used in the formula (I) doesn't belong to the following substances: enalapril (ACE inhibitors) and diclofenac (NSAID). Also, invention describes pharmaceutical compositions for using in cases of oxidative stress and 4-nitroxybutanoic acid 4'-acetylaminophenyl ester. Invention provides preparing novel compounds possessing useful biological properties. n EFFECT: valuable medicinal properties of medicinal substances and compositions. n 7 cl, 8 tbl, 32 ex |