| abstract |
FIELD: oncology. n SUBSTANCE: method comprises administering to an animal, requiring this treatment, in a synergetic mode, therapeutically effective amount of (i) agent selected from group including cytotoxic agents and cytostatic agents and (ii) compound of formula I (given in description) or pharmaceutically acceptable salt thereof. Method provides synergic antitumor effect when using diminished doses of one or both active ingredients, prevents or slows development of multidrug resistance of tumor while ensuring destruction of both proliferative and non-proliferative tumor cells. n EFFECT: enabled use of reduced doses of drugs. n 7 cl, 23 dwg, 6 tbl, 25 ex |