| abstract |
FIELD: organic chemistry, biochemistry, medicine, pharmacy. n SUBSTANCE: invention relates to new inhibitors of farnesyltransferase of the formula (I): n wherein R 1 means hydrogen atom (H), group of the formula R 5 C(O)- wherein R 5 means phenyl, pyridyl or N-methylpiperidine; R 2 means hydrogen atom (H), isopropyl, cyclopentyl or N-methyltetrahydropyridyl; R 3 means hydrogen atom (H), halogen atom; R 4 means hydrogen atom (H), halogen atom; L means -CH 2 -Z- wherein Z means NH; Y means sulfur atom (S), S(O) or S(O) 2 ; or its salt. Compounds of the formula (I) inhibit activity of enzyme, farnesyl(protein)transferase, that allows their using in pharmaceutical composition in cancer treatment. n EFFECT: valuable medicinal properties of inhibitors. n 18 cl, 3 tbl, 3 sch, 6 ex |