| abstract |
FIELD: organic chemistry, medicine, pharmacy. n SUBSTANCE: invention relates to new compounds of the general formula (1) n wherein A represents bicyclic or tricyclic azepine derivative; V 1 and V 2 both represent hydrogen atom (H) or one among V 1 and V 2 represents hydrogen atom (H), OMe, OBn, OPh, O-acyl, Br, Cl, F, N 3 , NH 2 , NHBn and another represents hydrogen atom (H); or V 1 and V 2 represent in common =O or -O(CH 2 ) p O-; W 1 represents oxygen (O) or sulfur (S) atom; X 1 and X 2 both represent hydrogen atom (H) or in common represent =O or =S; Y represents OR 5 or NR 6 R 7 ; R 1 means hydrogen atom (H), lower alkyl, F, Cl and Br; R 2 means lower alkoxy-group or values given for R 1 ; R 3 and R 5 are taken independently among hydrogen atom (H) and lower alkyl; R 4 means hydrogen atom (H); R 6 and R 7 are taken independently among hydrogen atom (H) and lower alkyl, or they in common mean -(CH 2 ) n -; n = 3, 4, 5 or 6; p = 2 or 3. These compounds are agonists of vasopressin V 2 receptors and useful as antidiuretic and procoagulants, and also to pharmaceutical compositions comprising these vasopressin agonists. These compositions are useful especially in treatment of diabetes insipidus of the central origin and night enuresis. n EFFECT: valuable medicinal properties of compounds, improved method for treatment. n 26 cl, 1 tbl, 119 ex |