| abstract |
FIELD: organic chemistry and pharmaceutical compositions. n SUBSTANCE: invention relates to new 3-(5)-heteroaryl-substituted pyrazoles of formula I , tautomers or pharmaceutically acceptable salt of compounds and tautomers. In formula R 1 is hydride, piperidinyl substituted with methyl, lower alkyl optionally substituted with halogen, hydroxyl, lower alkylanimo or morpholino; R 2 is hydride, lower alkyl, amino, aminocarbonylamino, lower alkylaminocarbonylamino, lower alkylsulfonylamino, aminosulfonylamino, lower alkylaminosulfonylamino; Ar 1 is phenyl optionally substituted with one or more independently selected halogen; HetAr 2 is pyridinyl with the proviso that R 2 is not amino or n-propyl when HetAr 2 is pyridinyl; and HetAr 2 is not 2-pyriridinyl when R 2 is hydrogen or lower alkyl. Compounds of formula I have kinase p38 inhibitor activity and are useful in pharmaceutical compositions for treatment of various diseases. n EFFECT: new effective kinase p38 inhibitors. n 23 cl, 6 dwg, 1 tbl, 1 ex |