http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2248977-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 |
| filingDate | 2000-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d36a3dfc755db3b140ca3ed8713d5b32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d08df64831411e25048decf5fedc4120 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d996ca60e76da199ea18e3e66d732d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_654d12a8a251ae57dff90613afe6f85a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bafa92f2e613bb8e5d98761a4f9638f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f49be1de3698f573c8bba1e1f2061a81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a0134028fdd2e38889dccf24f216246 |
| publicationDate | 2005-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2248977-C2 |
| titleOfInvention | Purine derivatives as inhibitors of tyrosine proteinase syk |
| abstract | FIELD: organic chemistry, heterocyclic compounds, biochemistry. n SUBSTANCE: invention relates to new compounds - purine derivatives of the general formula (I): in free form or salt wherein X means oxygen or sulfur atom or group NR 5 ; R 1 means alkyl, alkenyl, cycloalkyl, benzocycloalkyl, cycloalkylalkyl or aralkyl group that can be substituted optionally with hydroxy-, carboxy-group or alkoxycarbonyl; or if X means NR 5 then R 1 can mean alternatively heterocyclic group taken among benzylpiperidyl or the formula: ; or group of the formula (II): ; R 2 means hydrogen atom, alkyl or alkoxy-group; R 3 means hydrogen atom, alkoxy-, carboxy-group, carboxyalkyl, alkoxycarbonyl, -N(R 9 )R 10 , (C 1 -C 4 )-alkylene-SO 2 N(R 11 )R 12 or -CON(R 13 )R 14 ; or if two substitutes R 2 and R 3 are joined to adjacent carbon atoms in indicated benzene ring then in common with carbon atoms to which they are joined they mean heterocyclic group comprising 5-10 ring atoms among them one or two atoms mean heteroatoms taken among nitrogen, oxygen and sulfur atom; R 4 means hydrogen atom, alkoxy-, carboxy-group, carboxyalkyl, -SO 2 N(R 11 )R 12 , -N(R 9 )R 10 or -CON(R 13 )R 14 ; or if two substitutes R 3 and R 4 are joined to adjacent carbon atoms in indicated benzene ring then in common with carbon atoms to which they are joined they mean heterocyclic group comprising 5-6 ring atoms among them one or two atoms mean heteroatoms taken among nitrogen, oxygen or sulfur atom; R 5 means hydrogen atom or alkyl; R 6 , R 7 and R 8 mean hydrogen atom, or one of these radicals means -SO 2 NH 2 , -N(CH 3 )COCH 3 , -CONH 2 and two others mean hydrogen atom; R 9 means hydrogen atom or alkyl; R 10 means hydrogen atom, -COR 15 wherein R 15 means alkyl, alkoxy-group; or R 9 and R 10 in common with nitrogen atom to which they are joined mean heterocyclic group comprising 5 or 6 ring atoms among them one or two atoms mean heteroatoms taken among nitrogen and oxygen atom; R 11 means hydrogen atom or alkyl; R 12 means hydrogen atom, alkyl, hydroxyalkyl, carboxyalkyl or alkoxycarbonylalkyl; or R 11 and R 12 in common with nitrogen atom to which they are joined mean heterocyclic group comprising 5 or 6 ring atoms among them one or two atoms mean heteroatoms taken among nitrogen and oxygen atom; R 13 and R 14 each and independently of one another means hydrogen atom or alkyl with exception of 2-(para-n-butylanilino)-6-methoxypurine, 2-(para-n-butylanilino)-6-(methylthio)purine, 2,6-di-(phenylamino)-purine, 2,6-di-(para-tolylamino)-purine and 2-(para-tolylamino)-6-(phenylamino)-purine. n EFFECT: valuable biochemical properties of compounds. n 11 cl, 4 tbl, 221 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2498987-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2570113-C1 |
| priorityDate | 1999-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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