| abstract |
FIELD: organic chemistry, chemical technology, medicine, pharmacy. n SUBSTANCE: invention relates to a method for preparing {2-[4-(α-phenyl-p-chlorobenzyl)piperazine-1-yl]ethoxy}acetic acid (cetirizine) of the formula (I): (I). n Method involves hydrolysis of compound of the formula (II): (II) n wherein R 1 and R 2 represent independently (C 1 -C 4 )-alkyl that can be substituted with phenyl, (C 2 -C 4 )-alkenyl or cyclohexyl; or R 1 and R 2 in common with adjacent nitrogen atom form morpholine group. Hydrolysis is carried if necessary in the presence of interphase catalyst. Cetirizine is used as a component in anti-allergic pharmaceutical compositions. Also, invention describes a method for preparing intermediate compounds of the formula (II). n EFFECT: improved preparing method, valuable medicinal properties of compound. n 5 cl, 25 ex |