| abstract |
FIELD: organic chemistry, steroids, medicine, pharmacy. n SUBSTANCE: invention relates to 3-methylene-steroid derivative of the general formula (1): n wherein R 1 means hydrogen atom (H), or in common with R 3 it forms β-epoxide; or R 1 is absent in the presence of 5-10-double bond; R 2 means (C 1 -C 5 )-alkyl; R 3 means βH, βCH 3 or in common with R 1 it forms β-epoxide; either R 3 is absent in the presence of 5-10-double bond; R 4 means hydrogen atom, lower alkyl; Y represents [H, H], [OH, H], [OH, (C 2 -C 5 )-alkenyl], [OH, (C 2 -C 5 )-alkynyl] or (C 1 -C 6 )-alkylidene, or =NOR 5 wherein R 5 means hydrogen atom (H), lower alkyl; dotted lines represent optional double bond. Compound can relate also to its prodrug used for treatment of arthritis and/or autoimmune diseases. n EFFECT: valuable medicinal properties of compounds, improved method for treatment. n 38 cl, 1 tbl, 18 ex |