| abstract |
FIELD: organic chemistry, steroids, pharmacy. n SUBSTANCE: invention describes unsaturated 14,15-cyclopropanoandrostanes of the general formula (I): n wherein R 1 means hydrogen atom (H), hydroxy-group (OH); R 2 means hydroxy-group (OH), hydrogen atom (H); R 3 means hydrogen atom (H), (C 1 -C 10 )-alkyl at α- or β-position; R 4 means halogen atom (F, Cl, Br) or pseudohalogen group (azide, rhodanide), hydroxy-group (OH), perfluoroalkyl; R 5 means (C 1 -C 4 )-alkyl; if double bond is at 1,2-position then R 4 can mean hydrogen atom (H). Also, invention relates to a method for preparing these compounds and pharmaceutical compositions containing these compounds. Compounds of the formula (I) are compounds eliciting gestagenic and/or androgenic effect. n EFFECT: improved preparing method, valuable medicinal properties of compounds. n 11 cl, 1 tbl, 9 ex |