| abstract |
FIELD: organic chemistry, medicine. n SUBSTANCE: invention describes N-substituted azaheterocyclic carboxylic acids and their esters of the formula (I): n wherein R 1 and R 2 represent independently hydrogen, halogen atom, NR 6 R 7 or (C 1 -C 6 )-alkyl; Y represents >N-CH 2 or >C=CH 2 - wherein only underlined atom is a component of the ring system; X represents -O-, -S-, -CH 2 CH 2 - wherein R 6 and R 7 represent independently (C 1 -C 6 )-alkyl; r = 1, 2 or 3; Z represents heterocycle taken among formulas (a), (b), (c), (d), (f), (k), (g) and (j) given in the invention claim. Also, invention relates to a method for their preparing and pharmaceutical composition based on compounds of the formula (I). Invention describes a method for inhibition of neurogenous pain, inflammation and blood glucose level increase to patient by administration to patient the effective dose of compound of the formula (I). Compounds of the formula (I) elicit ability to inhibit the neurogenous pain and blood glucose enhanced level. n EFFECT: improved preparing method, valuable medicinal properties of compounds. n 13 cl, 1 tbl, 30 ex |