http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2243214-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-612 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C53-132 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-28 |
| filingDate | 1999-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28dbac8413edf44ef430d84880d2b206 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98a551fc6934e21135dbf4aa6f866d33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2af507e7f023737855f2130adede511f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd1c8896bc1b355975b50c22d55dce1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_231b339347b2c6b2c9e1ddef0d8889e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_853e44d3f2c0eb36fc5e91ffe6bf3bea |
| publicationDate | 2004-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2243214-C2 |
| titleOfInvention | New derivatives and analogues of 3-arylpropionic acid |
| abstract | FIELD: organic chemistry, medicine, endocrinology, pharmacy. n SUBSTANCE: invention relates to new derivatives and analogues of 3-arylpropionic acid of the general formula (I) , n their seteroisomers, optical isomers and racemates and to their pharmaceutically acceptable salts. The group A in the indicated formula (I) is at meta- or para-position and it represents n wherein R represents hydrogen atom; -OR a wherein R a represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NR a R b wherein R a and R b are similar or different and represent hydrogen atom, alkyl, phenyl, alkylphenyl, cyano-group; R 1 represents alkyl, cyano-group; -OR e wherein R e represents alkyl, phenyl or alkylphenyl; -O-[CH 2 ] m -OR f wherein R f represents alkyl; m represents a whole number 1-2; -SR d wherein R d represents alkyl or phenyl; -SO 2 OR a wherein R a represents alkyl, phenyl or alkylphenyl; -COOR d wherein R d represents alkyl; R 2 represents hydrogen atom or alkyl; R 3 and R 4 are similar or different and each represents hydrogen atom or alkyl; n represents a whole number 1-3; D is at ortho-, meta- or position and represents -OSO 2 R d wherein R d represents alkyl, phenyl or alkylphenyl; -OCONR f R a wherein R f and R a represent hydrogen atom, alkyl, phenyl or alkylphenyl; -NR c COOR d wherein R c represents hydrogen atom or alkyl, and R d represents alkyl, phenyl or alkylphenyl; -NR c COR a wherein R c represents hydrogen atom or alkyl, and R a represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NR c R d wherein R c and R d represent hydrogen atom, alkyl, phenyl or alkylphenyl; -NR c SO 2 R d wherein R c represents hydrogen atom or alkyl, and R d represents alkyl, phenyl or alkylphenyl; -NR c CONR a R k wherein R c represents hydrogen atom, R a and R k are similar or different and each represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NR c CSNR a R k wherein R c represents hydrogen atom, R a and R k are similar or different and each represents hydrogen atom, phenyl or alkylphenyl; -SO 2 R d wherein R d represents alkyl, phenyl or alkylphenyl; -SR c wherein R c represents alkyl, phenyl or alkylphenyl; -SO 2 OR a wherein R a represents alkyl, phenyl or alkylphenyl; -CN; -CONR c R a wherein R c represents hydrogen atom or alkyl and R a represents hydrogen atom or alkyl; D is at meta-position and represents -OR f wherein R f represents alkyl, or it represents hydrogen atom; D'' is at ortho-, meta- or para-position and represents hydrogen atom wherein indicated alkyl a direct or branched alkyl group comprising from 1 to 6 carbon atoms, either cyclic alkyl comprising from 3 to 6 carbon atoms being indicated alkyl can be substituted with one or more group taken among alkyl, alkoxy-, halogen atom or phenyl wherein indicated phenyl can be substituted with one or more group taken among alkyl, alkoxy-, nitro-, thiol or halogen atom. Also, invention relates to a method for their preparing, pharmaceutical preparations comprising thereof and applying these compounds in clinical states associated with resistance to insulin. n EFFECT: valuable medicinal properties of compounds. n 41 cl, 109 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2494095-C2 |
| priorityDate | 1998-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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