| abstract |
FIELD: organic chemistry. n SUBSTANCE: invention relates to compounds of the formula (1): n n n n wherein R 1 , R 2 and R 3 represent independently one or more similar or different substitutes taken among the group consisting of hydrogen, halogen atom, hydroxy-group, mercapto-group, trifluoromethyl, amino-group, (C 1 -C 3 )-alkyl, (C 2 -C 3 )-olefin group, (C 1 -C 3 )-alkoxy-group, (C 1 -C 3 )-alkylthio-group, (C 1 -C 6) -alkylamino-group, (C 1 -C 3 )-alkoxycarbonyl, cyano-group, carbamoyl or phenyl; R 1 and R 2 are represented by nitro-group and R 3 - by carboxy-group additionally; R 4 represents hydrogen atom, (C 1 -C 3 )-alkyl or allyl; Q represents a bond or -C(R 6 )(R 7 )(-O-C=O)- wherein R 6 and R 7 mean independently hydrogen atom, trifluoromethyl or (C 1 -C 4 )-alkyl; Y represents either (C 5 -C 15 )-alkyl, (C 2 -C 15 )-olefin group, (C 3 -C 10 )-monocyclic hydrocarbon or phenyl being each of that can be substituted optionally with one or more similar or different substituted represented by the formula R 5 ; or Y represents (C 5 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 3 -C 6 )-cycloalkyl, (C 5 -C 8 )-cycloalkene group or phenyl bein each can be substituted optionally with one or more similar or different substituted taken among the group including halogen atom, hydroxy-group, amino-group, (C 1 -C 2 )-alkoxy-group, (C 1 -C 4 )-alkylamino-group, (C 1 -C 3 )-alkoxycarbonyl, cyano-group, azido-group, -COOH, -CONH 2 , -CONHR' or -CONRR', wherein R and R' mean (C 1 -C 2 )-alkyl; or Y represents (C 1 -C 4 )-alkyl substituted with at least one or more substituted of the formula R 5 or -CONRR' wherein R and R' mean (C 1 -C 2 )-alkyl; or Y represents group of the formula -CH 2 -(Z-O) n -Z wherein Z represents (C 1 -C 3 )-alkyl and wherein n represents a whole number > 1 being without continuous linear sequence of atoms in the group Y > 15; R 5 represents halogen atom, hydroxy-group, mercapto-group, trifluoromethyl, amino-group, (C 1 -C 3 )-alkoxy-group, (C 1 -C 3 )-alkylthio-group, (C 1 -C 6 )-alkylamino-group, (C 1 -C 3 )-alkoxycarbonyl, cyano-group, azido-group, nitro-group, -COOH, -CONH 2 , -CONHR', -COONR'R' wherein R' means (C 1 -C 3 )-alkyl; X means oxygen or sulfur atom; or pharmaceutically acceptable salts of this compound, or hydrates of this compound, or solvates of this compound that can be used for treatment of humans in veterinary science. n EFFECT: valuable medicinal and veterinary properties of compounds. n 8 cl, 2 tbl, 31 ex |