http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2238937-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4174 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate | 1999-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11559c72cb3a67623ea921da74c0f470 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acec8920ba36d4122db63d17212a2900 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a310f56111703125e22933ee410c9d99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40ce0bc42580f5e28e14dbd8ffc5fdc0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_618b541efd727b84f021cc9d54d962c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01c47b10dbf957f26c699b4ed0dc5abb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3896efa65dd619b88f49470af115cea3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77ff31dc9f25b32e8ffc259413eca485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fe1eec3156ad1219acd1c2c6fa60ee3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c7e8be6581f16ad643dde166f641c38 |
| publicationDate | 2004-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2238937-C2 |
| titleOfInvention | Derivatives of imidazole, pharmaceutical composition and method for prophylaxis and/or treatment based on thereof |
| abstract | FIELD: organic chemistry, medicine, pharmacy. n SUBSTANCE: invention relates to new derivatives of imidazole of the formula (I): n wherein R 1 represents phenyl or pyridinyl substituted with substituents taken among group comprising (1) phenyl, (2) furyl, thienyl, (3) halogen atom, (4) halogen-(lower)-alkyl, (5) lower alkylthio-group, (6) nitro-group, (7) lower alkenyl optionally substituted with phenyl, (8) lower alkynyl optionally substituted with phenyl, (9) lower alkoxy-group optionally substituted with cyclo-(lower)-alkyl or phenyl, (10) lower alkyl optionally substituted with phenoxy-group, or (11) amino-group optionally substituted with protected carboxyl; R 2 represents lower alkyl; R 3 represents halogen atom or lower alkyl; R 4 represents (1) lower alkenyl optionally substituted with phenyl, (2) phenyl optionally substituted with lower alkyl or lower alkenyl, (3) lower alkyl or (4) thienyl optionally substituted with halogen atom; A represents lower alkylene; L represents a simple bond, lower alkenylene or lower alkylene optionally substituted with phenyl or pyridinyl, or -X-CH 2 - wherein X represents oxygen atom (O) or NR 5 wherein R 5 represents hydrogen atom or lower alkyl, and to their salts. Invention relates also to a method for preparing compounds of the formula (I) and a pharmaceutical composition and the preparation eliciting hypoglycemic activity based on these compounds. Invention provides preparing new compounds and pharmaceutical preparations based on thereof for aims for prophylaxis and/or treatment of disturbances associated with deterioration of tolerance to glucose, diabetes mellitus, diabetes in pregnants, diabetic complications, resistance syndrome to insulin, ovary polycystosis syndrome, hyperlipidemia, atherosclerosis, cardiovascular diseases, hyperglycemia, pancreatitis, osteoporosis, hyperuricemia, hypertension, intestine inflammatory diseases, skin diseases associated with pathological differentiation of epidermal cells. n EFFECT: improved prophylaxis and treatment method, valuable medicinal properties of compounds and pharmaceutical composition. n 14 cl, 2 tbl, 76 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2538986-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2538506-C2 |
| priorityDate | 1998-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 861.