http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2235722-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 2001-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_721657004d719973249c2a0225c8d9ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_366eb632c16665f65a7691b59b974bb6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbe0fa748a5d2077b33a20f8f0e487a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b905f3872ce85cd0860091d02dac10c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50117d0a97b6f825b36fe2edd783ee6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_806e16cb2479179bb57bf685394c6750 |
| publicationDate | 2004-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2235722-C2 |
| titleOfInvention | 1-{n-[2-(diethylamino)ethyl]-n-[4-(4-trifluoromethylphenyl)-benzyl]aminoca rbonylmethyl}-2-(4-fluorobenzyl)thio-5,6-trimethylenepyrimidine-4-one or its pharmaceutically acceptable salt, method for preparing and pharmaceutical composition |
| abstract | FIELD: organic chemistry, chemical technology, medicine, pharmacy. n SUBSTANCE: invention relates to new 1-{N-[2-(diethylamino)ethyl]-N-[4-(4-trifluoromethylphenyl)-benzyl]aminocarbonylmethyl}-2-(4-fluorobenzyl)thio-5,6-trimethylenepyrimidine-4-one of the formula (I): n n n n or its pharmaceutically acceptable salt that elicit properties of inhibitor of enzyme Lp-PLA 2 and can be used for treatment or prophylaxis of morbidity state associated with activity of indicated enzyme. Such disease can be atherosclerosis and also diabetes, hypertension, stenocardia, reprefusion, ischemia, rheumatoid arthritis, Alzheimer's disease, myocardium infarction, sepsis, acute and chronic inflammation and psoriasis. Compounds can be used, in particular, for preparing a medicinal agent used for primary and secondary prophylaxis of acute coronary attacks. Compound of the formula (I) is prepared by interaction of compound of the formula (II): n n n n with compound of the formula (III): n under conditions of amide formation. Invention relates also to a pharmaceutical composition. n EFFECT: improved preparing method, valuable medicinal properties of compound. n 20 cl, 1 sch, 8 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I460176-B |
| priorityDate | 2000-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 229.