| abstract |
FIELD: organic chemistry, biochemistry, nucleic acids. SUBSTANCE: invention relates to bicyclonucleoside analogs of the general formula (1) and oligonucleotides based on thereof comprising one or some structural units of the general formula (1a) wherein R 1 represents hydrogen atom, protecting group, phosphoric acid group and others; R 2 represents azido-group or amino-group that can be substituted; B represents purine-9-yl or 2-oxo-1,2-dihydropyrimidine- 1-yl group that can be substituted with one or some substituents. Oligonucleotides can be used as anti-sense or antigenic agents. EFFECT: valuable biological and biochemical properties of compounds. 15 cl, 1 dwg, 3 tbl |