http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2227142-C2
Outgoing Links
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|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-335 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D313-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D313-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-335 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate | 1999-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42a469a8a3b44a81d1eb1577ee965232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7537f5a3a367b51016b94187e9b1aa0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec2d2e16cfd3acb44f9788bfb193efd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4971621d927a7399afae20afc8d7e679 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52594d749e1970b2f59d6ae547f61323 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea8fc445007535446dd78b21f04ea589 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52b92d11d9d4b93581509894b7f003ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46e416ff6565df90ae8b8ec025745c3d |
| publicationDate | 2004-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2227142-C2 |
| titleOfInvention | Derivatives of epotilone and methods for their preparing, pharmaceutical composition and method of treatment based on thereof |
| abstract | FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of epotilone of the formula (I) wherein a bond designated by wavy line means that the bond "a" is in cis- or in trans-form; (A) R 2 is absent or means oxygen atom; "a" means a simple or double bond; "b" is absent or means a simple bond; "c" is absent or means a simple bond under condition that if R 2 means oxygen atom then "b' and "c" both mean a simple bond and "a" means a simple bond; if R 2 is absent then "b" and "c" both are absent and "a" means a double bond; if "a" means a double bond then R 2 ,, "b" and "c" are absent; R 3 means radical taken among the group comprising hydrogen atom, (lower)alkyl being first of all methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert.-butyl, n-pentyl, n- hexyl; -OH; R 4 and R 5 mean independently of one another hydrogen atom; R 1 means radical of formulas: (a) , (b) , (c) , (d) ; (B) if R 3 means (lower)alkyl being first of all methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert.-butyl, n-pentyl, n-hexyl, , -OH and other symbols with exception of R 1 have values indicated above in (A) then R 1/ can mean radical of formulas: (e) , (f) , (g) , (h) , (i) also; (C) if R 3 means -OH and other symbols with exception of R 1 have above indicated values then R 1 can mean fragment of the formula (j) also; or salt of compound of the formula (I) if salt-forming group presents. Invention relates to pharmaceutical composition eliciting proliferative effect and containing compound of the formula (I) and pharmaceutically acceptable carrier. Invention relates to method for preparing compound of the formula (I) involving interaction of iodide of the formula (II) , a, b and c and a bond designated by wavy line have values indicated above with tin- -containing compound of the formula R 2 , R 3 , R 4 , R 5 , wherein has values indicated above and R means (lower)alkyl, methyl or n-butyl. Invention relates to method for preparing compound of the formula (I) involving interaction of tin-containing compound of the formula (IV) R 1/ with iodide of the formula -I and if necessary the conversion of formed compound of the formula (I) to another compound of the formula (I), the conversion of formed free compound of the formula (I) to salt of compound of the formula (I) and/or the conversion of formed salt of compound of the formula (I) to free compound of the formula (I) to other salt of compound of the formula (I), and/or separation of mixture of stereoisomers of compound of the formula (I) for corresponding isomers. Invention provides preparing new compounds eliciting proliferative effect. EFFECT: improved preparing methods, valuable medicinal properties of compounds, improved treatment method. 18 cl, 3 tbl |
| priorityDate | 1998-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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