http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2218399-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88 |
| filingDate | 2001-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23f417e5c56a80319b61634e490cbd4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf739f621d04248e6a6ca16f33dcfe72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73fa2bf2e94c951226af943d8f4bcb0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3441762be8a2f5ee9fcb50922dd79b98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff07f3fdcf1a6e6d1a052270baa56ee1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6625c106b4edd072d9976b7ac169ffb7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65ad42a39009ca8c657bbf6aa0f76bda http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_916475e45f345aa7a7f5f18defb178ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_783f52d688e1fa652ab6c5af9de3aa43 |
| publicationDate | 2003-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2218399-C2 |
| titleOfInvention | Inhibitor of no-dependent activation of soluble form of guanylate cyclase |
| abstract | FIELD: organic chemistry, biochemistry, enzymes. SUBSTANCE: invention can be used in biochemistry for study of regulatory effects of nitrogen oxide and mechanism of action of peroxide-containing sesquiterpenoids of artemisinine order on activity of soluble form of guanylate cyclase (sGC). Invention relates to artemisinine and its derivatives of the general formula (I): wherein if is a simple bond then R is OH, (lower alkyl)-hydroxy-group or OC(O)CH 2 CH 2 C(O)ONa; or if is a double bond then R is oxygen atom. These compounds in the concentration 1-100 mcM show inhibitory effect of NO-dependent activation of sGC partially purified from human platelets caused by donor of nitrogen oxide - sodium nitroprusside. Concentration of artemisinine providing 50% of reduction of activating effect of sodium nitroprusside (IC 50 ) is 4.2 mcM being "basal" activity of enzyme (in the absence of sodium nitroprusside) is increased insignificantly (by 20-24%). Methylene blue as the nearest structural analogue in the concentration 10 mcM under the same conditions inhibits NO-dependent activation of sGC by 27% and reduces "basal" activity of enzyme by 10- 15%. Peroxide-containing sesquiterpenoids of artemisinine order of the general formula (I) are new effective inhibitors of NO-dependent activation of sGC. EFFECT: valuable biochemical properties of inhibitor, expanded assortment of modulating agents for this enzyme. 2 dwg, 1 tbl, 4 ex |
| priorityDate | 2001-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 119.